Research

Scientific data presentations and peer-reviewed papers from ImmunityBio

How Can ImmunityBio Help You?

Solutions for Patients

Many cancer therapies, including radiation therapy, chemotherapy, CAR-T therapy, and B-cell immunotherapy, severely weaken the immune system—the human body’s most important natural disease-fighting weapon. But ImmunityBio creates targeted, personalized immunotherapies that are designed to strengthen the immune system and enable it to outsmart your disease.
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Opportunities for Trial Investigators

The broad therapeutic potential and demonstrated safety of ImmunityBio’s immune-enhancing IL-15 superagonist Anktiva (N-803), engineered NK-92® cell-based therapies, and our next-generation adenovirus-vectored anti-cancer vaccines make them appealing therapeutics for testing by trial investigators who want to make a contribution to clinical cancer research. Interested clinicians and other are encouraged to contact ImmunityBio to find out how they may support discovery of future cancer treatments.
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Tools for Research Scientists

Our NK-92® easy-to-maintain and highly cytotoxic natural killer cell line provides a versatile bioanalytical testing tool that can help researchers develop functional killing assays that are more consistent and reliable than donor blood and reporter gene assays.
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ImmunityBio is continuously pursuing new immunotherapies designed to attack disease by enhancing the patient’s immune system, not weakening it.

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ANKTIVA Synergizes with T Cell Activity of BCG in Both the Naïve and Unresponsive…
May 2, 2024
Presentation
 
Targeting sinonasal undifferentiated carcinoma with a combinatory immunotherapy approach
Apr 10, 2024
Peer-reviewed article
 
Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed…
Feb 29, 2024
Peer-reviewed article
 
CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1…
Feb 27, 2024
Peer-Reviewed Publication
 
Quality of Life in the Phase 2/3 Trial of N-803 Plus BCG in BCG-Unresponsive Non-Muscle…
Jan 16, 2024
Peer-Reviewed Publication
 
Safety and virologic impact of haploidentical NK cells plus IL-2 or N-803 in HIV infection
Jan 11, 2024
Peer-reviewed article
 
Characterization of the anti-tumor activity of memory cytokine enriched NK cells (M-ceNK)…
Nov 4, 2023
Poster
 
AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral…
Oct 2, 2023
Peer-reviewed article
 
Caveolin Gene Expression Predicts Clinical Outcomes for Early-Stage HER2-Negative Breast…
Sep 1, 2023
Peer-Reviewed Publication
 
Exploiting an Interleukin-15 Heterodimeric Agonist (N803) for Effective Immunotherapy of…
Jul 12, 2023
Peer-Reviewed Publication
 
Inferred immune-cell activity is an independent predictor of HER2 negative breast cancer…
Jul 5, 2023
Peer-Reviewed Publication
 
The NK-92 cell line-30 years later: its impact on natural killer cell research and…
May 25, 2023
Peer-Reviewed Publication
 
Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T…
Apr 13, 2023
Peer-Reviewed Publication
 
An Interleukin-15 Superagonist Enables Antitumor Efficacy of Natural Killer Cells Against…
Mar 18, 2023
Peer-Reviewed Publication
 
Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated…
Dec 14, 2022
Peer-Reviewed Publication
 
IL-15 Superagonist NAI in BCG-Unresponsive Non–Muscle-Invasive Bladder Cancer
Nov 10, 2022
Peer-Reviewed Publication
 
A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
Nov 2, 2022
Peer-Reviewed Publication
 
Control of Simian Immunodeficiency Virus Infection in Prophylactically Vaccinated,…
Oct 26, 2022
Peer-Reviewed Publication
 
IL-15 Superagonist N-803 Enhances IFN-γ Production of MAIT Cells in SIV(+) Macaques
Oct 20, 2022
Peer-Reviewed Publication
 
Enhanced neoepitope-specific immunity following neoadjuvant PD-L1 and TGF-β blockade in…
Sep 15, 2022
Peer-Reviewed Publication
 
Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust…
Jul 15, 2022
Peer-Reviewed Publication
 
Phase 2 QUILT 88 trial of DAMP inducers combined with IL15 superagonist, N-803 and anti…
Jun 3, 2022
Poster
 
QUILT 3032: Final clinical results of pivotal trial of IL-15RαFc superagonist N-803 with…
Jun 3, 2022
Presentation
 
ASCO 2022 Annual Meeting Oral Presentation
Jun 3, 2022
Presentation
 
Phase I Trial Characterizing the Pharmacokinetic Profile of N-803, a Chimeric IL-15…
Mar 15, 2022
Peer-Reviewed Publication
 
Safety, Feasibility, and Merits of Longitudinal Molecular Testing of Multiple Metastatic…
Mar 6, 2022
Peer-Reviewed Publication
 
Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a…
Feb 28, 2022
Peer-Reviewed Publication
 
Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer…
Feb 24, 2022
Peer-Reviewed Publication
 
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally…
Feb 23, 2022
Peer-Reviewed Publication
 
Phase II/III clinical results of IL-15RαFc superagonist N-803 with BCG in…
Feb 18, 2022
Presentation
 
A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors…
Feb 15, 2022
Peer-Reviewed Publication
 
CCR7 expression in CD19 chimeric antigen receptor-engineered natural killer cells…
Feb 13, 2022
Peer-Reviewed Publication
 
Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA…
Feb 8, 2022
Peer-Reviewed Publication
 
QUILT-88: NANT Pancreatic Cancer Vaccine in 3rd, 4th, & 5th Line Advanced Disease
Jan 20, 2022
Poster
 
Combinatorial Natural Killer Cell-based Immunotherapy Approaches Selectively Target…
Dec 1, 2021
Peer-Reviewed Publication
 
Dual-Antigen COVID-19 Vaccine Subcutaneous Prime Delivery With Oral Boosts Protects NHP…
Sep 16, 2021
Peer-Reviewed Publication
 
Therapeutic Potential of IL-15 and N-803 in HIV/SIV Infection
Sep 2, 2021
Peer-Reviewed Publication
 
A deep learning-based iterative digital pathology annotation tool
Aug 24, 2021
Pre-print
 
Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine…
Jul 23, 2021
Peer-Reviewed Publication
 
Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo…
Jul 9, 2021
Peer-Reviewed Publication
 
Identification and validation of expressed HLA-binding breast cancer neoepitopes for…
Jun 9, 2021
Peer-Reviewed Publication
 
Prime hAd5 Spike + Nucleocapsid Vaccination Induces Ten-Fold Increases in Mean T-Cell…
Jun 9, 2021
Pre-print
 
Preliminary data from QUILT 3.055: a phase 2 multi-cohort study of N803 (IL-15…
Jun 4, 2021
Poster
 
Safety, Tolerability, and Long-Term Clinical Outcomes of an IL-15 analogue (N-803)…
May 3, 2021
Peer-Reviewed Publication
 
Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with…
Apr 8, 2021
Peer-Reviewed Publication
 
Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with…
Apr 8, 2021
Peer-Reviewed Publication
 
Single Prime hAd5 Spike (S) + Nucleocapsid (N) Dual Antigen Vaccination of Healthy…
Apr 7, 2021
Pre-print
 
Phase I study of a multitargeted recombinant Ad5 PSA/MUC-1/brachyury-based immunotherapy…
Mar 9, 2021
Peer-Reviewed Publication
 
Chimeric antigen receptor engineered NK cellular immunotherapy overcomes the selection of…
Mar 9, 2021
Peer-Reviewed Publication
 
Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and…
Jan 13, 2021
Pre-print
 
Inability of granule polarization by NK cells defines tumor resistance and can be…
Jan 9, 2021
Peer-Reviewed Publication
 
Novel cytokine-antibody fusion protein, N-820, to enhance the functions of ex vivo…
Oct 8, 2020
Peer-Reviewed Publication
 
Combination of CD8β Depletion and Interleukin-15 Superagonist N-803 Induces Virus…
Sep 15, 2020
Peer-Reviewed Publication
 
Complete response to avelumab and IL-15 superagonist N-803 with Abraxane in Merkel cell…
Sep 10, 2020
Peer-Reviewed Publication
 
Natural Born Killers: NK Cells in Cancer Therapy
Jul 31, 2020
Peer-Reviewed Publication
 
A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and…
Jul 30, 2020
Pre-print
 
Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells
Jul 7, 2020
Publication
 
Interleukin-15 superagonist (N-803) treatment of PML and JCV in a post-allogeneic…
Jun 9, 2020
Peer-Reviewed Publication
 
PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and…
May 20, 2020
Publication
 
Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15…
Apr 16, 2020
Publication
 
Overcoming hypoxia-induced functional suppression of NK cells
Apr 8, 2020
Publication
 
The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK…
Mar 12, 2020
Peer-Reviewed Publication
 
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
Feb 5, 2020
Peer-Reviewed Publication
 
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
Feb 5, 2020
Peer-Reviewed Publication
 
A deep learning image-based intrinsic molecular subtype classifier of breast tumors…
Jan 28, 2020
Peer-Reviewed Publication
 
IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian…
Jan 28, 2020
Peer-Reviewed Publication
 
NANT Triple Negative Breast Cancer (TNBC) Vaccine: Molecularly-Informed Integrated…
Dec 11, 2019
Poster
 
Interaction kinetics with transcriptomic and secretory responses of CD19-CAR natural…
Nov 26, 2019
Publication
 
Mechanisms of resistance to T cell-based immunotherapy in head and neck cancer
Nov 26, 2019
Peer-Reviewed Publication
 
Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA…
Oct 25, 2019
Peer-Reviewed Publication
 
Adenoviral vector-based vaccine is fully protective against lethal Lassa fever challenge…
Oct 23, 2019
Publication
 
Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15…
Oct 23, 2019
Peer-Reviewed Publication
 
Efficient ADCC killing of meningioma by avelumab and a high-affinity natural killer cell…
Oct 17, 2019
Publication
 
A Phase I Trial Using a Multitargeted Recombinant Adenovirus 5 (CEA/MUC1/Brachyury)-Based…
Oct 8, 2019
Publication
 
Efficient Tumor Clearance and Diversified Immunity through Neoepitope Vaccines and…
Aug 7, 2019
Peer-Reviewed Publication
 
Innate and adaptive immunotherapy: An orchestration of immunogenic cell death by…
May 26, 2019
Publication
 
Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy
Mar 21, 2019
Peer-Reviewed Publication
 
Direct and antibody-dependent cell-mediated cytotoxicity of head and neck squamous cell…
Mar 9, 2019
Peer-Reviewed Publication
 
CAR-Expressing Natural Killer Cells for Cancer Retargeting
Feb 5, 2019
Publication
 
NANT cancer vaccine an orchestration of immunogenic cell death by overcoming immune…
Jan 29, 2019
Peer-Reviewed Publication
 
Immunotherapy utilizing the combination of natural killer- and antibody dependent…
Nov 29, 2018
Peer-Reviewed Publication
 
The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the…
Nov 27, 2018
Publication
 
Phase I Trial of ALT-803, A Novel Recombinant IL15 Complex, in Patients with Advanced…
Nov 15, 2018
Publication
 
In vitro Evidence That Combination Therapy With CD16-Bearing NK-92 Cells and FDA-Approved…
Nov 5, 2018
Publication
 
First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat…
Jun 7, 2018
Publication
 
Comprehensive genomic transcriptomic tumor-normal gene panel analysis for enhanced…
Apr 10, 2018
Peer-Reviewed Publication
 
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic…
Apr 5, 2018
Publication
 
ALT-803 Transiently Reduces Simian Immunodeficiency Virus Replication in the Absence of…
Feb 1, 2018
Publication
 
The human IL-15 superagonist ALT-803 directs SIV-specific CD8(+) T cells into B-cell…
Jan 23, 2018
Publication
 
Clinical grade manufacturing of genetically modified, CAR-expressing NK-92 cells for the…
Jan 1, 2018
Publication
 
CD16(+)NK-92 and anti-CD123 monoclonal antibody prolongs survival in primary human acute…
Jan 1, 2018
Publication
 
Providing a Homing Receptor for CAR Engineered NK Cells – Improving Cellular…
Jan 1, 2018
Poster
 
CD56bright NK cells exhibit potent antitumor responses following IL-15 priming.
Nov 1, 2017
Publication
 
Analyses of functions of an anti-PD-L1/TGFβR2 bispecific fusion protein (M7824).
Sep 26, 2017
Publication
 
IL-15 super-agonist (ALT-803) enhances natural killer (NK) cell function against ovarian…
Jun 1, 2017
Publication
 
Identification and characterization of enhancer agonist human cytotoxic T-cell epitopes…
May 2, 2017
Peer-Reviewed Publication
 
Continuously expanding CAR NK-92 cells display selective cytotoxicity against B-cell…
Feb 19, 2017
Peer-Reviewed Publication
 
An NK cell line (haNK) expressing high levels of granzyme and engineered to express the…
Dec 27, 2016
Peer-Reviewed Publication
 
Intra-Tumor Injection of CAR-Engineered NK Cells Induces Tumor Regression and Protection…
Dec 2, 2016
Abstract
 
A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody…
Nov 11, 2016
Publication
 
CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell…
Jul 20, 2016
Peer-Reviewed Publication
 
High-throughput identification of neoepitopes for the development of patient-specific…
Jul 15, 2016
Abstract
 
Construction and Immunogenicity Testing of Whole Recombinant Yeast-Based T-Cell Vaccines
Apr 14, 2016
Peer-Reviewed Publication
 
A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to…
Apr 1, 2016
Publication
 
IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803)…
Mar 29, 2016
Publication
 
The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In…
Feb 1, 2016
Publication
 
Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term…
Jan 1, 2016
Publication
 
Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in…
Jan 1, 2016
Publication
 
Advances in clinical NK cell studies: Donor selection, manufacturing and quality control
Nov 11, 2015
Peer-Reviewed Publication
 
The generation and analyses of a novel combination of recombinant adenovirus vaccines…
Sep 7, 2015
Peer-Reviewed Publication
 
An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression…
Sep 1, 2015
Publication
 
Extended evaluation of a phase 1/2 trial on dosing, safety, immunogenicity, and overall…
Aug 1, 2015
Publication
 
Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced…
Jan 1, 2014
Publication
 
Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing…
Aug 1, 2013
Publication
 
Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15…
May 15, 2013
Publication
 
Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus…
Nov 26, 2012
Publication
 
A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors.
Oct 1, 2012
Publication
 
Prevention of influenza virus shedding and protection from lethal H1N1 challenge using a…
Sep 16, 2011
Publication
 
Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector…
Jul 1, 2010
Publication
 
Novel Adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag,…
Oct 30, 2009
Publication
 
Feb 17, 1989
Publication
 
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