Research

Scientific data presentations and peer-reviewed papers from ImmunityBio

Solutions for Patients

ImmunityBio creates targeted, personalized immunotherapies that are designed to strengthen the immune system and enable it to outsmart your disease.

Opportunities for Trial Investigators

Next-generation adenovirus-vectored anti-cancer vaccines make appealing therapeutics for testing by trial investigators who want to make a contribution to clinical cancer research.

Tools for Research Scientists

Our NK-92® easy-to-maintain and highly cytotoxic natural killer cell line provides a versatile bioanalytical testing tool that can help researchers develop functional killing assays that are more consistent and reliable than donor blood and reporter gene assays.

ImmunityBio is continuously pursuing new immunotherapies designed to attack disease by enhancing the patient’s immune system, not weakening it.

About Us
Poster
Abstract 890: Abstract 890: NK-92® (aNK™) whole cell lysate exerts potent cytotoxic…
Apr 21, 2025
Poster
Abstract 894: Generation of cytokine-induced memory-like PD-L1 t-haNK (NK-92®) cells
Apr 21, 2025
Poster
Abstract 885: Generation and characterization of NK-92® (aNK ) cells with…
Apr 15, 2025
Presentation
ANKTIVA Synergizes with T Cell Activity of BCG in Both the Naïve and Unresponsive…
May 2, 2024
Peer-reviewed article
Targeting sinonasal undifferentiated carcinoma with a combinatory immunotherapy approach
Apr 10, 2024
Peer-reviewed article
Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed…
Feb 29, 2024
Peer-Reviewed Publication
CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1…
Feb 27, 2024
Peer-Reviewed Publication
Quality of Life in the Phase 2/3 Trial of N-803 Plus BCG in BCG-Unresponsive Non-Muscle…
Jan 16, 2024
Peer-reviewed article
Safety and virologic impact of haploidentical NK cells plus IL-2 or N-803 in HIV infection
Jan 11, 2024
Poster
Characterization of the anti-tumor activity of memory cytokine enriched NK cells (M-ceNK)…
Nov 4, 2023
Peer-reviewed article
AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral…
Oct 2, 2023
Peer-Reviewed Publication
Caveolin Gene Expression Predicts Clinical Outcomes for Early-Stage HER2-Negative Breast…
Sep 1, 2023
Peer-Reviewed Publication
Exploiting an Interleukin-15 Heterodimeric Agonist (N803) for Effective Immunotherapy of…
Jul 12, 2023
Peer-Reviewed Publication
Inferred immune-cell activity is an independent predictor of HER2 negative breast cancer…
Jul 5, 2023
Peer-Reviewed Publication
The NK-92 cell line-30 years later: its impact on natural killer cell research and…
May 25, 2023
Peer-Reviewed Publication
Reverse Translation Identifies the Synergistic Role of Immune Checkpoint Blockade and…
May 3, 2023
Peer-Reviewed Publication
Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T…
Apr 13, 2023
Peer-Reviewed Publication
An Interleukin-15 Superagonist Enables Antitumor Efficacy of Natural Killer Cells Against…
Mar 18, 2023
Peer-Reviewed Publication
Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated…
Dec 14, 2022
Peer-Reviewed Publication
IL-15 Superagonist NAI in BCG-Unresponsive Non–Muscle-Invasive Bladder Cancer
Nov 10, 2022
Peer-Reviewed Publication
A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
Nov 2, 2022
Peer-Reviewed Publication
Control of Simian Immunodeficiency Virus Infection in Prophylactically Vaccinated,…
Oct 26, 2022
Peer-Reviewed Publication
IL-15 Superagonist N-803 Enhances IFN-γ Production of MAIT Cells in SIV(+) Macaques
Oct 20, 2022
Peer-Reviewed Publication
Enhanced neoepitope-specific immunity following neoadjuvant PD-L1 and TGF-β blockade in…
Sep 15, 2022
Peer-Reviewed Publication
Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust…
Jul 15, 2022
Poster
Phase 2 QUILT 88 trial of DAMP inducers combined with IL15 superagonist, N-803 and anti…
Jun 3, 2022
Presentation
QUILT 3032: Final clinical results of pivotal trial of IL-15RαFc superagonist N-803 with…
Jun 3, 2022
Presentation
ASCO 2022 Annual Meeting Oral Presentation
Jun 3, 2022
Peer-Reviewed Publication
Phase I Trial Characterizing the Pharmacokinetic Profile of N-803, a Chimeric IL-15…
Mar 15, 2022
Peer-Reviewed Publication
Safety, Feasibility, and Merits of Longitudinal Molecular Testing of Multiple Metastatic…
Mar 6, 2022
Peer-Reviewed Publication
Phase I Trial Characterizing the Pharmacokinetic Profile of N-803, a Chimeric IL-15…
Mar 6, 2022
Peer-Reviewed Publication
Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a…
Feb 28, 2022
Peer-Reviewed Publication
Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer…
Feb 24, 2022
Peer-Reviewed Publication
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally…
Feb 23, 2022
Presentation
Phase II/III clinical results of IL-15RαFc superagonist N-803 with BCG in…
Feb 18, 2022
Peer-Reviewed Publication
A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors…
Feb 15, 2022
Peer-Reviewed Publication
CCR7 expression in CD19 chimeric antigen receptor-engineered natural killer cells…
Feb 13, 2022
Peer-Reviewed Publication
Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA…
Feb 8, 2022
Poster
QUILT-88: NANT Pancreatic Cancer Vaccine in 3rd, 4th, & 5th Line Advanced Disease
Jan 20, 2022
Peer-Reviewed Publication
Combinatorial Natural Killer Cell-based Immunotherapy Approaches Selectively Target…
Dec 1, 2021
Peer-Reviewed Publication
Dual-Antigen COVID-19 Vaccine Subcutaneous Prime Delivery With Oral Boosts Protects NHP…
Sep 16, 2021
Peer-Reviewed Publication
Therapeutic Potential of IL-15 and N-803 in HIV/SIV Infection
Sep 2, 2021
Pre-print
A deep learning-based iterative digital pathology annotation tool
Aug 24, 2021
Peer-Reviewed Publication
Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine…
Jul 23, 2021
Peer-Reviewed Publication
Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo…
Jul 9, 2021
Peer-Reviewed Publication
Identification and validation of expressed HLA-binding breast cancer neoepitopes for…
Jun 9, 2021
Pre-print
Prime hAd5 Spike + Nucleocapsid Vaccination Induces Ten-Fold Increases in Mean T-Cell…
Jun 9, 2021
Poster
Preliminary data from QUILT 3.055: a phase 2 multi-cohort study of N803 (IL-15…
Jun 4, 2021
Peer-Reviewed Publication
Safety, Tolerability, and Long-Term Clinical Outcomes of an IL-15 analogue (N-803)…
May 3, 2021
Peer-Reviewed Publication
Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with…
Apr 8, 2021
Peer-Reviewed Publication
Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with…
Apr 8, 2021
Pre-print
Single Prime hAd5 Spike (S) + Nucleocapsid (N) Dual Antigen Vaccination of Healthy…
Apr 7, 2021
Peer-Reviewed Publication
Phase I study of a multitargeted recombinant Ad5 PSA/MUC-1/brachyury-based immunotherapy…
Mar 9, 2021
Peer-Reviewed Publication
Chimeric antigen receptor engineered NK cellular immunotherapy overcomes the selection of…
Mar 9, 2021
Pre-print
Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and…
Jan 13, 2021
Peer-Reviewed Publication
Inability of granule polarization by NK cells defines tumor resistance and can be…
Jan 9, 2021
Peer-Reviewed Publication
Novel cytokine-antibody fusion protein, N-820, to enhance the functions of ex vivo…
Oct 8, 2020
Peer-Reviewed Publication
Combination of CD8β Depletion and Interleukin-15 Superagonist N-803 Induces Virus…
Sep 15, 2020
Peer-Reviewed Publication
Complete response to avelumab and IL-15 superagonist N-803 with Abraxane in Merkel cell…
Sep 10, 2020
Peer-Reviewed Publication
Natural Born Killers: NK Cells in Cancer Therapy
Jul 31, 2020
Pre-print
A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and…
Jul 30, 2020
Publication
Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells
Jul 7, 2020
Peer-Reviewed Publication
Interleukin-15 superagonist (N-803) treatment of PML and JCV in a post-allogeneic…
Jun 9, 2020
Publication
PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and…
May 20, 2020
Publication
Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15…
Apr 16, 2020
Publication
Overcoming hypoxia-induced functional suppression of NK cells
Apr 8, 2020
Peer-Reviewed Publication
The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK…
Mar 12, 2020
Peer-Reviewed Publication
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
Feb 5, 2020
Peer-Reviewed Publication
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
Feb 5, 2020
Peer-Reviewed Publication
A deep learning image-based intrinsic molecular subtype classifier of breast tumors…
Jan 28, 2020
Peer-Reviewed Publication
IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian…
Jan 28, 2020
Poster
NANT Triple Negative Breast Cancer (TNBC) Vaccine: Molecularly-Informed Integrated…
Dec 11, 2019
Publication
Interaction kinetics with transcriptomic and secretory responses of CD19-CAR natural…
Nov 26, 2019
Peer-Reviewed Publication
Mechanisms of resistance to T cell-based immunotherapy in head and neck cancer
Nov 26, 2019
Peer-Reviewed Publication
Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA…
Oct 25, 2019
Publication
Adenoviral vector-based vaccine is fully protective against lethal Lassa fever challenge…
Oct 23, 2019
Peer-Reviewed Publication
Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15…
Oct 23, 2019
Publication
Efficient ADCC killing of meningioma by avelumab and a high-affinity natural killer cell…
Oct 17, 2019
Publication
A Phase I Trial Using a Multitargeted Recombinant Adenovirus 5 (CEA/MUC1/Brachyury)-Based…
Oct 8, 2019
Peer-Reviewed Publication
Efficient Tumor Clearance and Diversified Immunity through Neoepitope Vaccines and…
Aug 7, 2019
Publication
Innate and adaptive immunotherapy: An orchestration of immunogenic cell death by…
May 26, 2019
Peer-Reviewed Publication
Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy
Mar 21, 2019
Peer-Reviewed Publication
Direct and antibody-dependent cell-mediated cytotoxicity of head and neck squamous cell…
Mar 9, 2019
Publication
CAR-Expressing Natural Killer Cells for Cancer Retargeting
Feb 5, 2019
Peer-Reviewed Publication
NANT cancer vaccine an orchestration of immunogenic cell death by overcoming immune…
Jan 29, 2019
Peer-Reviewed Publication
Immunotherapy utilizing the combination of natural killer- and antibody dependent…
Nov 29, 2018
Publication
The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the…
Nov 27, 2018
Publication
Phase I Trial of ALT-803, A Novel Recombinant IL15 Complex, in Patients with Advanced…
Nov 15, 2018
Publication
In vitro Evidence That Combination Therapy With CD16-Bearing NK-92 Cells and FDA-Approved…
Nov 5, 2018
Publication
First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat…
Jun 7, 2018
Peer-Reviewed Publication
Comprehensive genomic transcriptomic tumor-normal gene panel analysis for enhanced…
Apr 10, 2018
Publication
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic…
Apr 5, 2018
Publication
ALT-803 Transiently Reduces Simian Immunodeficiency Virus Replication in the Absence of…
Feb 1, 2018
Publication
The human IL-15 superagonist ALT-803 directs SIV-specific CD8(+) T cells into B-cell…
Jan 23, 2018
Publication
Clinical grade manufacturing of genetically modified, CAR-expressing NK-92 cells for the…
Jan 1, 2018
Publication
CD16(+)NK-92 and anti-CD123 monoclonal antibody prolongs survival in primary human acute…
Jan 1, 2018
Poster
Providing a Homing Receptor for CAR Engineered NK Cells – Improving Cellular…
Jan 1, 2018
Publication
CD56bright NK cells exhibit potent antitumor responses following IL-15 priming.
Nov 1, 2017
Publication
Analyses of functions of an anti-PD-L1/TGFβR2 bispecific fusion protein (M7824).
Sep 26, 2017
Publication
IL-15 super-agonist (ALT-803) enhances natural killer (NK) cell function against ovarian…
Jun 1, 2017
Peer-Reviewed Publication
Identification and characterization of enhancer agonist human cytotoxic T-cell epitopes…
May 2, 2017
Peer-Reviewed Publication
Continuously expanding CAR NK-92 cells display selective cytotoxicity against B-cell…
Feb 19, 2017
Peer-Reviewed Publication
An NK cell line (haNK) expressing high levels of granzyme and engineered to express the…
Dec 27, 2016
Abstract
Intra-Tumor Injection of CAR-Engineered NK Cells Induces Tumor Regression and Protection…
Dec 2, 2016
Publication
A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody…
Nov 11, 2016
Peer-Reviewed Publication
CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell…
Jul 20, 2016
Abstract
High-throughput identification of neoepitopes for the development of patient-specific…
Jul 15, 2016
Peer-Reviewed Publication
Construction and Immunogenicity Testing of Whole Recombinant Yeast-Based T-Cell Vaccines
Apr 14, 2016
Publication
A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to…
Apr 1, 2016
Publication
IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803)…
Mar 29, 2016
Publication
The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In…
Feb 1, 2016
Publication
Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term…
Jan 1, 2016
Publication
Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in…
Jan 1, 2016
Peer-Reviewed Publication
Advances in clinical NK cell studies: Donor selection, manufacturing and quality control
Nov 11, 2015
Peer-Reviewed Publication
The generation and analyses of a novel combination of recombinant adenovirus vaccines…
Sep 7, 2015
Publication
An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression…
Sep 1, 2015
Publication
Extended evaluation of a phase 1/2 trial on dosing, safety, immunogenicity, and overall…
Aug 1, 2015
Publication
Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced…
Jan 1, 2014
Publication
Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing…
Aug 1, 2013
Publication
Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15…
May 15, 2013
Publication
Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus…
Nov 26, 2012
Publication
A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors.
Oct 1, 2012
Publication
Prevention of influenza virus shedding and protection from lethal H1N1 challenge using a…
Sep 16, 2011
Publication
Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector…
Jul 1, 2010
Publication
Novel Adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag,…
Oct 30, 2009
Publication
Feb 17, 1989
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