ImmunityBio Pipeline

* Investigator-sponsored studies

nogapendekin alfa inbakicept, NAI and N-803 is an interleukin-15 superagonist fusion protein that is designed to induce expansion of native NK and CD8+ T-cells without concurrent stimulation of T-regulatory cells and (Aldox) is a proprietary albumin-bound doxorubicin complex that is designed to preferentially accumulate in a tumor’s low pH environment. Both agents are in late-stage clinical development by ImmunityBio, which has exclusive, worldwide rights to the agents. Pembrolizumab, sold under the brand KEYTRUDA®, is an FDA-approved immune checkpoint inhibitor marketed by Merck.
QUILT stands for QUantum Integrative Lifelong Trial.

Solutions for Patients

ImmunityBio creates targeted, personalized immunotherapies that are designed to strengthen the immune system and enable it to outsmart your disease.

Opportunities for Trial Investigators

Next-generation adenovirus-vectored anti-cancer vaccines make appealing therapeutics for testing by trial investigators who want to make a contribution to clinical cancer research.

Tools for Research Scientists

Our NK-92® easy-to-maintain and highly cytotoxic natural killer cell line provides a versatile bioanalytical testing tool that can help researchers develop functional killing assays that are more consistent and reliable than donor blood and reporter gene assays.

ImmunityBio is continuously pursuing new immunotherapies designed to attack disease by enhancing the patient’s immune system, not weakening it.

Advanced Solid Tumors

QUILT-3.076
Locally Advanced or Metastatic Solid Tumors
M-ceNK + nogapendekin alfa inbakicept
NCT04898543
Phase 1

Bladder Cancer

QUILT-3.032
BCG Unresponsive NMIBC Carcinoma In-Situ & Papillary
BCG + nogapendekin alfa inbakicept
NCT03022825
ACCEPTED

Bladder Cancer

QUILT-2.005
BCG Naïve NMIBC
BCG + nogapendekin alfa inbakicept
NCT02138734
Phase 2

Bladder Cancer (BCG Replacement)

ResQ133A
Recombinant BCG (rBCG)
NCT06800963
Phase 1 / 2

Colorectal/Lynch Syndrome

QUILT-5.015
Lynch Syndrome (NCI)
nogapendekin alfa inbakicept + Tri-Ad5 vaccines
NCT05419011
Phase 2

Glioblastoma

QUILT-3.078
Recurrent GBM or Progressive GBM
bevacizumab + nogapendekin alfa inbakicept + PD-L1 t-haNK
NCT06061809
Phase 2

HIV

AIDS Clinical Trials Group (ACTG) / National Institute of Allergy and Infectious Diseases…
nogapendekin alfa inbakicept
NCT04340596
Phase 1

HIV

Thailand Trial: N-803 in Acute HIV Infection*
nogapendekin alfa inbakicept
NCT04505501
Phase 2

HPV

QUILT-3.100
HPV+ / HPV- 2nd Line Head & Neck Cancer
nogapendekin alfa inbakicept + Ad5 HPV
NCT05976828
Phase 1

Lung Cancer

ResQ201A
Non-Small Cell Lung Cancer
nogapendekin alfa inbakicept + Tislelizumab
NCT06745908
Phase 3

Lymphopenia

ResQ117EX-ALC
Lymphopenia
nogapendekin alfa inbakicept
NCT06956547
Phase 1

Non-Hodgkin Lymphoma

QUILT-3.092
Relapses/Refractory Non-Hodgkin Lymphoma
CD19 t-haNK + nogapendekin alfa inbakicept
NCT05618925
Phase 1

Ovarian Cancer

ResQ-209
Planned – Platinum-Resistant Ovarian Cancer
M-ceNK + nogapendekin alfa inbakicept
NCT06710288
Phase 2
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