ImmunityBio Pipeline
DISEASE
INVESTIGATIONAL THERAPEUTICS
TRIAL SITES/COLLABORATORS
PHASE
* Investigator-sponsored studies
Anktiva® (N-803) is an interleukin-15 superagonist fusion protein that is designed to induce expansion of native NK and CD8+ T-cells without concurrent stimulation of T-regulatory cells and (Aldox) is a proprietary albumin-bound doxorubicin complex that is designed to preferentially accumulate in a tumor’s low pH environment. Both agents are in late-stage clinical development by ImmunityBio, which has exclusive, worldwide rights to the agents. Pembrolizumab, sold under the brand KEYTRUDA®, is an FDA-approved immune checkpoint inhibitor marketed by Merck.
QUILT stands for QUantum Integrative Lifelong Trial.
How Can ImmunityBio Help You?
ImmunityBio is continuously pursuing new immunotherapies designed to attack disease by enhancing the patient’s immune system, not weakening it.
Disease
Bladder Cancer
QUILT-3.032
BCG Unresponsive NMIBC Carcinoma In-Situ & Papillary
Trial Sites/Collaborators
32 study locations (see clinicaltrials.gov for details)
Phase
Disease
Bladder Cancer
QUILT-2.005
BCG Naïve NMIBC
Trial Sites/Collaborators
24 study locations (see clinicaltrials.gov for details)
Phase
Disease
Lung Cancer
QUILT-3.055
Non-Small Cell Lung Cancer
Trial Sites/Collaborators
31 study locations (see clinicaltrials.gov for details)
Phase
Disease
Colorectal/Lynch Syndrome
QUILT-5.015
Lynch Syndrome (NCI)
Trial Sites/Collaborators
National Cancer Institute (see clinicaltrials.gov for details)
Phase
Disease
Ovarian Cancer
ResQ-209
Planned – Platinum-Resistant Ovarian Cancer
Trial Sites/Collaborators
Details to be announced
Phase
Disease
HPV
QUILT-3.100
HPV+ / HPV- 2nd Line Head & Neck Cancer
Trial Sites/Collaborators
Chan Soon-Shiong Institute for Medicine (El Segundo, CA)
Phase
Disease
Glioblastoma
QUILT-3.078
Recurrent GBM or Progressive GBM
Trial Sites/Collaborators
Details to be announced
Phase
Disease
Advanced Solid Tumors
QUILT-3.076
Locally Advanced or Metastatic Solid Tumors
Trial Sites/Collaborators
Chan Soon-Shiong Institute for Medicine (El Segundo, CA)
Phase
Disease
Non-Hodgkin Lymphoma
QUILT-3.092
Relapses/Refractory Non-Hodgkin Lymphoma
Trial Sites/Collaborators
Hoag Memorial Presbyterian Hospital (Newport Beach, CA)
Phase
Disease
HIV
AIDS Clinical Trials Group (ACTG) / National Institute of Allergy and Infectious Diseases (NIAID): HIV Cure Study*
Trial Sites/Collaborators
See clinicaltrials.gov for details.
Phase
Disease
HIV
Rockefeller University: N-803 +/- 2 bNABs*
Trial Sites/Collaborators
See clinicaltrials.gov for details.
Phase
Disease
HIV
Thailand Trial: N-803 in Acute HIV Infection*
Trial Sites/Collaborators
See clinicaltrials.gov for details.
Phase
Disease
HIV
NIAID / University of Minnesota: Effect of N-803 on B Cell Follicles in Antiretroviral Treated HIV Disease*
Trial Sites/Collaborators
See clinicaltrials.gov for details.
Phase